Memetics has become a popular and widely-used concept/method in many areas, including cultural studies. However, I believe Memetics has some fundamental methodological problems. In this article, I have tried to show some of my main concerns regarding this methodological movement. Memetics uses the fact that Darwinian evolution is merely an abstract algorithm that can be applied to anything as long as it meets three main criteria (explained in details bellow). Memetics, is a form of theories of cultural evolution which tries to show a strong analogy between how genes evolve and how memes, defined as the units of culture, evolve. I have tried to show that drawing such a strong analogy, which is the defining characteristics of Memetics, is a mistake.